Covid-19 is an infectious disease whose etiological agent called SARS-CoV-2. It has a high
contagion rate, high morbidity and mortality, and potential multi-organ compromise. Its main
route of infection is by droplets, however, the infection can be acquired by other routes such
as aerosols, fecal-oral and contact with fomites. Although the immune response is essential
for defense against any infection, in severe Covid-19 infection, a dysregulation of the immune
system occurs, which leads to marked increases of cytokines and the consequent systemic
inflammatory state. Inflammation, infection, and viral shedding can compromise the lungs,
blood vessels, brain, gastrointestinal (GI) tract, kidneys, heart, and liver, ultimately leading to
multiple organ dysfunction and failure.
Faúndes G, N., Genskowsky V, K., & Tordecilla F, R. (2021). Patogenia de la infección por SARS-CoV-2. Revista Hospital Clínico Universidad De Chile, 32(2), pp. 107–117. https://doi.org/10.5354/2735-7996.2021.69651
