Klebsiella pneumoniae is an important agent of nosocomial inf ections, and is often associated to multidrug antibiotic resistance that limit therapeutic options. A study was performed to characterize antibiotic resistance amongK. pneumoniae isolates identified in nosocomial infection at our hospital.
18 isolates (from 17 patients) collected between January and July 1997 were analyzed according to the Kirby-Bauer procedure, and characterized according to antibiotyping, cluster analysis and phenotypic identification of known B-lactamases.
Results showed a high percentage of resistance against trimetroprim-sulfamethoxazol, cloramphenicol, ciprofloxacin, gentamicin and cephalosporins.
Furthermore, a high percentage of isolates demonstrated resistance against B-lactams-B-lactamase inhibitors combinations. Antibiotyping and cluster analysis indicated 3 phenotypic grups, characterized by a minar group (22%) of highly susceptible strains and two multiresistant groups, being one of these, associated with an outbreak in an intensive care unit.
Phenotypic identification of known B-lactamases suggests that extended spectrum B-lactamases are prevalent and hyperproduced in highly resistant isolates.
Sakurada Z., A., Fica C., A. ., Ruiz, G. ., & Ruiz M. , M. . (1998). Caracterización fenotípica de la resistencia antibiótica en aislamiento de Klebsiella pneumoniae asociadas a infecciones intrahospitalarias. Revista Hospital Clínico Universidad De Chile, 1998(9), pp. 11–17. https://doi.org/10.5354/2735-7996.1.80997
