NK ce/Is functionality during pregnancy. Ouring the last few years, the role of innate immune system in development of pre-eclampsia has been the focus of a number of studies. However, the role of
natural killer (NK) ce/Is in pregnancy and pre-eclampsia has not been total/y clarified. NK ce/Is, an important component of innate immune system, normal/y exhibit spontaneus cytolytic activity and secrete cytokines such as interferon gamma (IFN-y] and tumor necrosis factor
alpha {TNF-a]. In current paper, we studied functional activity and immunophenotype of peripheral blood NK cells obtained from patients with pre-eclampsia, healthy pregnant women and non pregnant healthy women. For this purpose, we quantified cytolytic activity using 51chromium release assay. We determined cytokine production in response to polyclonal activators and ce/Is immunophenotype (CD3-CD 16 + CD56 +) by flow cytometry. We found no significant differences in these parameters among the three groups studied, however,• in patients with pre-eclampsia, there is a tendency to a decreased cytotoxic activity and /ess production of TNFa by NK ce/Is in vitro as we/1 as an increased proportion of the NK subset CD56-C016+, in peripheral blood.
Salinas, J. ., lglesias, M. ., Osorio, A. ., Sepúlveda, C. ., Hidalgo, K. ., Puente, J., Fernández, J. ., & Afani, A. . (2004). Estudio de la funcionalidad de las células NK en el embarazo. Revista Hospital Clínico Universidad De Chile, 15(4), pp. 316–24. https://doi.org/10.5354/2735-7996.2004.79193
