Diversidad clínica de las infecciones invasivas por Streptococcus pyogenes y asociación con el superantígeno SpeA.

Authors

  • Alberto Fica C. Hospital Clínico Universidad de Chile. Unidad de lnfectología.
  • María Teresa Ulloa F. Universidad de Chile
  • Carolina Llanos M. Universidad de Chile
  • Amaranta Luzoro V. Universidad de Chile
  • Lorena Porte T. Universidad de Chile
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Abstract

Severe infections associated to Streptococcus pyogenes have emerged in Chile. We present a series of 5 patients admitted to our Hospital during 1999. All of them had bacteremia and associated morbid factors . Three patients evolved with shock, and 2 of them presented the Streptococcal toxic shock syndrome. Three patients had cutaneous rnanifestations and 2 had clotting disturbances. All patients presented high white cell counts (16800 /mm3 on average) and higher C reactive protein values (mean 300 mg/L) . Band cells percentages and erithrosedimentation rates were variables and some patients had normal values. Four patients underwent surgical interventions and 3 patients received intravenous gammaglobulin. Three patients died in this group and survivors had a prolonged hospitalization beyond one mouth. All bacterial isolates harbored the speA superantigen-codifying gene.

Keywords:

Infecciones Estreptocócicas/inmunología , Streptococcus pyogenes/patogenicidad , Antibacterianos/uso terapéutico , Bacteriemia/inmunología