Moduladores Selectivos de Receptores de Estrógeno

Authors

  • Mario Pardo Hospital Clínico Universidad de Chile. Departamento Obstetricia y Ginecología. Unidad de Mastología.
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Abstract

In the menopausal women the advantages of the estrogen therapy are undebatable especially when it comes to the osseous and cardiovascular system. The inconvenience is that they are associated with a moderate increase in the relative risk of developrug breast and endometrial cancer. This paper reviews the new generation of estrogens known as selective estrogen receptor modulators (SERMS). The SERMS have a selective estrogenic effect on specific target organs and do not act on the reproductive system. We analyze its mechanism of action, its clinical value and the future perspectives of this new product.

Keywords:

Moduladores Selectivos de los Receptores de Estrógeno/metabolismo , Moduladores selectivos de receptores de estrógeno/administración & dosificación , Moduladores selectivos de receptores de estrógeno/uso terapéutico , Posmenopausia/efectos de los fármacos , Terapia de Reemplazo de Estrógeno/efectos adversos