Oxygen-derived free radicals after free flap reperfusion were investigated in a clinical rnodel. Superoxide blood levels prior and after reperfusion were quantified in a patient who underwent breast reconstruction with a free TRAM flap. Collection of blood s11n1ples rvere obtained from free flap via a venous route.
Superoxide levels were quantified by a chemiluminescence method. Elevation of blood oxygen-derived free radical levels were correlated with successful vascular patency after reperfusion. A prospective clinical series will be necessary.
Our findings appear to demonstrate that a free flap is an excellent model to study ischemia reperfusion injury and the superoxide levels are a promising clinical marker wich can predict vascular insufficiency during reperfusion following tissue ischemia.
Sepúlveda, S. ., Valenzuela, O. ., Behn, C. ., Galaz, J. ., Manieu, D. ., Merino, D. ., Palma, C. ., & Araneda, O. . (2001). Producción de radicales libres en colgajo microvascular: Un modelo para estudiar daño isqt1émico post reperfusión. Caso clínico. Revista Hospital Clínico Universidad De Chile, 12(2), pp. 129–33. https://doi.org/10.5354/2735-7996.2001.79934
